MAST Research Featured in AIChE CEP Magazine

We are proud to share that our research has been featured in the AIChE - American Institute of Chemical Engineers CEP magazine for May. Kudos to our talented researchers for their outstanding work!

In collaboration with Christopher Yehl at Spark Therapeutics, MAST Center researchers Ranil Wickramasinghe, Xianghong Qian, Ronny Horax, Andrew Zydney, and Akshay Chaubal have developed a single-pass tangential flow filtration (SPTFF) process for the purification and concentration of AAV clarified cell lysates (CCL). From the article:

"Unlike traditional TFF, SPTFF concentrates AAV vectors along the length of an appropriately staged membrane device in a single pass without any recycling. The high concentration factor is achieved by optimizing the flow and pressure distribution within the staged device to minimize membrane fouling, which can occur due to the accumulation of AAV material at the membrane surface. In addition to the reduced process shear, SPTFF can also increase productivity by enhancing the performance of subsequent capture chromatography step(s)."

This achievement underscores the power of industry-academic partnerships in advancing bioprocess innovation.

Congratulations to everyone involved—this is a significant leap forward for gene therapy manufacturing! #BioprocessInnovation #GeneTherapy #AAV #IndustryAcademicPartnerships #MASTCenter

Read more HERE.